Avicel® PH - 113 composed of microcrystalline cellulose, finds application in tablet formulations. Manufactured using direct compression, dry granulation, and wet granulation techniques, it serves as a binder and compression aid. Derived from non-animal sources, it meets pharmaceutical and nutraceutical standards.

Chemical Name: Cellulose, Microcrystalline

CAS Number: 9004-34-6

Dosage Form: Tablets

Labeling Claims: APE-free, Allergen-free, Aluminum-free, Amine-free, Antibiotics-free, BSE-free, Bisphenol A-free, Caffeine Free, Colorants-free, Dioxin-free, Dye Free, Endocrine Disruptor-free, Ethylene Oxide-free, GMO-free, Generally Recognized As Safe (GRAS), Glycerin-free, Halal, Heavy Metal-free, Hormones-free, Impurities-free, Kosher, Latex-free, Monosodium Glutamate (MSG)-free, Natural Latex Rubber-Free, Nitrosamines-free, Non-GMO, PAH-free, PFAS-Free, PFOS-free, PHO (Partially Hydrogenated Oil)-Free, PVC-free, Palm Oil-free, Paraben-free, Perfluorooctanoic Acid-free, Pesticide-free, Phthalates-free, Plasticizer-free, Preservative-free, Sugar-free, TSE-free, Tributyl Tin Compounds-Free, Triphenyl Tin Compounds-Free, Vegan, Vegetarian

Certifications & Compliance: British Pharmacopeia (BP), Doping-Free, EU Cosmetic Regulation 1223/2009 Compliant, EXCiPACT, European Pharmacopeia (Ph. Eur.), European Regulation 396/2005/EC, FDA Compliant, FDA Food Safety Modernization Act (FSMA), FSSC 22000, Generally Recognized As Safe (GRAS), Halal, Hazard Analysis Critical Control Point (HACCP), ICH Q3C, IFRA Compliant, ISO 22000, Japan Pharmacopeia (JP), Kosher, National Formulary (NF), Regulation (EU) No. 1272/2008, Regulation (EU) No. 231/2012, United States Pharmacopeia (USP), cGMP

Manufacturing Technology: Direct Compression, Dry Granulation, Wet Granulation

Synonyms: Crystalline cellulose, Micro Fibril Cellulose, Pyrocellulose

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Enhanced TDS

Identification & Functionality

Features & Benefits

Applications & Uses

Properties

Physical Form
Soluble in
Copper Tetrammine Hydroxide
Typical Properties
ValueUnitsTest Method / Conditions
Typical Degree Polymerization Range100 - 300--
Physico-Chemical Properties
ValueUnitsTest Method / Conditions
Loss on Drying*max. 2%-
Bulk Density0.27 - 0.34g/cc-
Identification (A,B)*Pass--
Degree of Polymerizationmax. 350units-
pH*5.5 - 7.0--
Conductivitymax. 75μS/cm-
Residue on Ignitionmax. 0.05%-
Water Soluble Substancesmax. 12.5mg/5g-
Water Soluble Substancesmax. 0.25%-
Ether Soluble Substancesmax. 5.0mg/10g-
Microbiological Values
ValueUnitsTest Method / Conditions
Total Aerobic Microbial Countmax. 100*cfu/g-
Yeast and Mold Count (Total)*max. 20cfu/g-
Pseudomonas aeruginosaAbsent/10g-
E. coliAbsent/10g-
Staphylococcus aureusAbsent/10g-
Salmonella SpeciesAbsent/10g-
ColiformAbsent/10g-
Specifications
ValueUnitsTest Method / Conditions
Particle Size Distribution (D50)32-78--
Particle Size (Air Jet, + 60 mesh, 250 microns)max. 1wt%-
Particle Size (Air Jet, + 200 mesh, 75 microns)max. 30wt%-
Heavy Metals
ValueUnitsTest Method / Conditions
Heavy Metalsmax. 0.001%-
Note

*More restrictive than compendium

Regulatory & Compliance

Technical Details & Test Data

Nutritional Information

Typical Nutrient Information/100g

US EU/Australia/NZ
Total calories 0 cal 194 cal
Calories from fat 0 cal 0 cal
Total fat 0 g 0 g
Saturated fat 0 g 0 g
Cholesterol 0 mg 0 mg
Sodium 5 mg 5 mg
Salt NA 0.01 g
Total carbohydrate 97 g 0 g
Total dietary fiber 97 g 97 g
Insoluble fiber 97 g 97 g
Soluble fiber 0 g 0 g
Sugar 0 g 0 g
Protein 0 g 0 g
Vitamin A 0 mg 0 mg
Vitamin C 0 mg 0 mg
Calcium 1 mg 1 mg
Iron 0.2 mg 0 mg
Ash 0 g 0 g
Magnesium 0 mg 0 mg
Potassium 0 mg 0 mg
Moisture 3 g 3 g

Storage & Handling

Shelf Life
4 years
Storage Conditions

Store at ambient conditions. Keep containers sealed; material is very hygroscopic.IFF recommends that after the above re- evaluation date, the customer perform the loss on drying test.