Avicel® RC - 591 is versatile, catering to various dosage forms like lotions, sprays, and suspensions. Its manufacturing technology involves direct compression, dry granulation, and wet granulation methods. In pharmaceutical and nutraceutical applications, it serves as a binder, compression aid, immediate release agent, and stabilizer, ensuring product efficacy and stability.

Chemical Name: Cellulose, Microcrystalline, Cellulose, carboxymethyl ether, sodium salt

Dosage Form: Lotions, Spray, Suspension

Labeling Claims: APE-free, Allergen-free, Aluminum-free, Antibiotics-free, BSE-free, Bisphenol A-free, Caffeine Free, Colorants-free, Dioxin-free, Dye Free, Endocrine Disruptor-free, Ethylene Oxide-free, GMO-free, Generally Recognized As Safe (GRAS), Glycerin-free, Halal, Hormones-free, Kosher, Latex-free, Monosodium Glutamate (MSG)-free, Natural Latex Rubber-Free, Non-GMO, PAH-free, PFAS-Free, PFOS-free, PHO (Partially Hydrogenated Oil)-Free, PVC-free, Palm Oil-free, Paraben-free, Perfluorooctanoic Acid-free, Pesticide-free, Phthalates-free, Plasticizer-free, Preservative-free, Sugar-free, TSE-free, Tributyl Tin Compounds-Free, Triphenyl Tin Compounds-Free, Vegetarian

Certifications & Compliance: British Pharmacopeia (BP), Doping-Free, EU Cosmetic Regulation 1223/2009 Compliant, EXCiPACT, European Pharmacopeia (Ph. Eur.), European Regulation 396/2005/EC, FDA Compliant, FDA Food Safety Modernization Act (FSMA), GMP, Generally Recognized As Safe (GRAS), Halal, ICH Q3C, IFRA Compliant, Japanese Pharmaceutical Excipients (JPE), Kosher, National Formulary (NF), Regulation (EU) No. 1272/2008, Regulation (EU) No. 231/2012, United States Pharmacopeia (USP), cGMP

Manufacturing Technology: Direct Compression, Dry Granulation, Wet Granulation

  • TypeDocument Name
View All Documents

Enhanced TDS

Identification & Functionality

Features & Benefits

Applications & Uses

Properties

Physical Form
Physico-Chemical Properties
ValueUnitsTest Method / Conditions
Loss on Dryingmax. 6%G 5-6
Viscosity (1.2% Solids, 120 Second)39 - 175cPsA 11a-4
Assay for Carboxymethylcellulose Sodium (Based on NF Equivalency)9 - 15%A 11 – 1
pH6 - 8-A 11 - 5
Heavy Metalsmax. 0.001%G 5-7
Sieve Fraction (60 mesh)max. 0.1-G 5 - 9a
Sieve Fraction (325 mesh)max. 75wt%G 5 - 9a
Residue on Ignitionmax. 5.0wt%G 5-11
IdentificationPass-A 11 - 2b
Microbiological Values
ValueUnitsTest Method / Conditions
Total Aerobic Plate Countmax. 1000cfu/gM 20 - 19
Yeast and Mold Countmax. 100cfu/gM 20 - 20
Pseudomonas aeruginosaNone Present/10gM 20 - 21
E. coliNone Present/10gM 20 - 22
Staphylococcus aureusNone Present/10gM 20 - 23
Salmonella SpeciesNone Present/10gM 20 - 24
Specifications
ValueUnitsTest Method / Conditions
NaCMC Content8.3 - 13.8%-
Viscosity (at 2.6% Solid)39 - 91cPs-

Regulatory & Compliance

Technical Details & Test Data

Typical Nutrient Information/100g
  US EU/Australia/NZ
Estimated Caloric Value 18 Cal

189 Cal/ 790 kJoules

Calories from Fat 0 Cal 0 Cal
Total Fat 0 g 0 g
Saturated Fat 0 g 0 g
Trans-Fat 0 g 0 g
Polyunsaturated Fat 0 g 0 g
Monounsaturated Fat 0 g 0 g
Cholesterol 0 mg 0 mg
Sodium 940 mg 940 mg
Salt -g 2.35 g
Potassium 0 mg 0 mg
Total Carbohydrate 94 g 0 g
Sugars (Total) 0 g 0 g
Added Sugars 0 g 0 g
Starch 0 g 0 g
Total Dietary Fiber 85 g 94 g
Dietary Fiber (Soluble) 0 g 9 g
Dietary Fiber (Insoluble) 85 g 85 g
Protein 0 g 0 g
Vitamin A 0 mcg 0 mcg
Vitamin C 0 mg 0 mg
Vitamin D 0 mcg 0 mcg
Calcium 1 mg 1 mg
Iron 0.3 mg 0.3 mg
Phosphorous 0 mg 0 mg
Magnesium 1 mg 1 mg
Moisture 4 g 4 g
Ash 2 g 2 g
Organic acid 0 g 0 g

US: Calories = [(Total Carbs + Protein) * 4 Cal/g + (Fat * 9 Cal/g)]. Soluble fiber is included in Total Carbs, but calorie contribution is calculated at 2 Cal/g. In the US, food manufacturers have the option to exclude the amount of insoluble fiber from the calorie calculation.
EU: Calories = ([Carbs (sugars + starch ) + Protein] * 4 Cal/g) + (Fat * 9 Cal/g) + (All dietary fiber * 2 Cal/g) + (Organic acids * 3 Cal/g)). In Europe, fiber is listed separately and is not included in the carb content. Other calorie conversion factors exist, none of which is relevant to this product.

Dispersing and activating Avicel® cMCC for functionality

Avicel® cMCC suspending aids demonstrate thixotropic properties, forming gel-like structures at rest and exhibiting shear thinning during shaking and handling. Figure 2 shows the shear thinning that occurs at various shear rates and levels of Avicel® RC-591 in deionized water. Figure 3 shows a schematic to portray the recovery of viscosity and gel-like structure after shaking and handling. This thixotropic behavior profile allows viscous formulations to be thinned for easy swallowing with the shake of a bottle, consistently keeping the desirable mouthfeel until the liquid is poured and swallowed. The gel-like structure recovers with time, ensuring formulation stability and content uniformity during storage.

Activating the gel-like structure is vital to achieving the desired suspension performance. With options for both high- and low-shear dispersion processes, it is no wonder Avicel® cMCC is the industry-leading colloidal MCC for diverse applications.

Avicel® CL-611 can be used where low shear is preferred, enabling the gel-like structure to build and activate in both liquid and reconstitutable suspensions. For liquid formulations, recommended use level starts at ~2.4 percent. For dispersion of dry powders that will be mixed into water, levels of 4 percent or more are recommended to achieve the desired functionality.

Figure 2: Thixotropic characteristics of Avicel® RC-591.

Avicel® RC - 591 - Dispersing and activating Avicel® cMCC for functionality - 2

Figure 3: Avicel® RC-591 viscosity consistency at rest (a), during shaking and handling (b), and recovery post handling (c).

Avicel® RC - 591 - Dispersing and activating Avicel® cMCC for functionality - 1

Storage & Handling

Shelf Life
3 years
Shelf Life Information

Three years from date of manufacture shown on product label. This applies to unopened packages, stored under dry and cool conditions.