Avicel® SMCC - 50 is used in tablet formulations, employing various manufacturing technologies like direct compression, dry granulation, and wet granulation. It serves multiple functions in pharmaceutical and nutraceutical applications, including acting as a binder, compression aid, filler, and immediate release agent.

Chemical Name: Cellulose, Microcrystalline

CAS Number: 9004-34-6

Dosage Form: Tablets

Labeling Claims: APE-free, Aflatoxin-free, Allergen-free, Aluminum-free, Amine-free, Antibiotics-free, BSE-free, Bisphenol A-free, Caffeine Free, Colorants-free, Dioxin-free, Dye Free, Gluten-free, Glycerin-free, Halal, Hormones-free, Impurities-free, Irradiation-free, Kosher, Latex-free, Mercury-Free, Monosodium Glutamate (MSG)-free, Natural Latex Rubber-Free, Nitrosamines-free, Non-GMO, Not Listed In California Proposition 65, PAH-free, PFAS-Free, PFOS-free, PHO (Partially Hydrogenated Oil)-Free, PVC-free, Palm Oil-free, Paraben-free, Perfluorooctanoic Acid-free, Pesticide-free, Phthalates-free, Plasticizer-free, Preservative-free, Solvent-free, Sugar-free, TSE-free, Tributyl Tin Compounds-Free, Triphenyl Tin Compounds-Free, Vegan, Vegetarian, Zinc-free

Certifications & Compliance: British Pharmacopeia (BP), Chinese Pharmacopeia (ChP), EXCiPACT, European Pharmacopeia (Ph. Eur.), European Regulation 396/2005/EC, FDA Compliant, FDA Food Safety Modernization Act (FSMA), FSSC 22000, Generally Recognized As Safe (GRAS), Halal, Hazard Analysis Critical Control Point (HACCP), ICH Q3C, ISO 22000, ISO 9001, Japan Pharmacopeia (JP), Kosher, National Formulary (NF), Regulation (EU) No. 1272/2008, Regulation (EU) No. 231/2012, United States Pharmacopeia (USP), cGMP

Manufacturing Technology: Direct Compression, Dry Granulation, Wet Granulation

Synonyms: Crystalline cellulose, Micro Fibril Cellulose, Pyrocellulose

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Enhanced TDS

Identification & Functionality

Features & Benefits

Applications & Uses

Properties

Physical Form
Physico-Chemical Properties
ValueUnitsTest Method / Conditions
Loss on Drying (More restrictive than compendium)max. 6.0%-
Bulk Density0.25 - 0.37g/mL-
Identification (A,B,C,D)Pass--
Degree of Polymerizationmax. 350units-
pH (More restrictive than compendium)5.0 - 7.0--
Conductivitymax. 75μS/cm-
Residue on Ignition1.8 - 2.2%-
Water Soluble Substances (More restrictive than compendium)max. 0.24%-
Ether Soluble Substancesmax. 0.05%-
Heavy Metalsmax. 0.001%-
SolubilityPass--
Microbiological Values
ValueUnitsTest Method / Conditions
Total Aerobic Microbial Count (More restrictive than compendium)max. 100cfu/g-
Yeast and Mold Count (Total, More restrictive than compendium)max. 20cfu/g-
Pseudomonas aeruginosaAbsent/10g-
E. coliAbsent/10g-
Staphylococcus aureusAbsent/10g-
Salmonella SpeciesAbsent/10g-
Particle Size Distribution
ValueUnitsTest Method / Conditions
Particle Size (D10)15 - 30--
Particle Size (D50)45 - 80--
Particle Size (Air Jet, 60 mesh, 250 microns)max. 1.0wt%-
Particle Size (Air Jet, 200 mesh, 75 microns)10.0 - 30.0wt%-

Regulatory & Compliance

Technical Details & Test Data

Typical Nutrient Information/100g
  US EU/Australia/NZ
Estimated Caloric Value 0 Cal

190 Cal/ 794 kJoules

Calories from Fat 0 Cal 0 Cal
Total Fat 0 g 0 g
Saturated Fat 0 g 0 g
Trans-Fat 0 g 0 g
Polyunsaturated Fat 0 g 0 g
Monounsaturated Fat 0 g 0 g
Cholesterol 0 mg 0 mg
Sodium 5 mg 5 mg
Salt - g 0.01 g
Potassium 0 mg 0 mg
Total Carbohydrate 0 g 0 g
Sugars (Total) 0 g 0 g
Added Sugars 0 g 0 g
Starch 0 g 0 g
Total Dietary Fiber 95 g 95 g
Dietary Fiber (Soluble) 0 g 0 g
Dietary Fiber (Insoluble) 95 g 95 g
Protein 0 g 0 g
Vitamin A 0 mcg 0 mcg
Vitamin C 0 mg 0 mg
Vitamin D 0 mcg 0 mcg
Calcium 1 mg 1 mg
Iron 0 mg 0 mg
Magnesium 0 mg 0 mg
Moisture 3 g 3 g
Ash 2 g 2g
Organic acid 0 g 0 g

Storage & Handling

Shelf Life
4 years
Shelf Life Information

Store at ambient conditions. Keep containers sealed; material is very hygroscopic. Re-evaluation date is four (4) years from date of manufacture, if storage conditions stated above are observed. IFF recommends that after the above re-evaluation date, the customer perform the loss on drying test. Typical Degree Polymerization range for Avicel PH microcrystalline cellulose is 100 to 300.