Avicel® SMCC - 50 is used in tablet formulations, employing various manufacturing technologies like direct compression, dry granulation, and wet granulation. It serves multiple functions in pharmaceutical and nutraceutical applications, including acting as a binder, compression aid, filler, and immediate release agent.

Chemical Name: Cellulose, Microcrystalline

CAS Number: 9004-34-6

Dosage Form: Tablets

Labeling Claims: APE-free, Allergen-free, Aluminum-free, Antibiotics-free, BSE-free, Bisphenol A-free, Caffeine Free, Colorants-free, Dioxin-free, Dye Free, Glycerin-free, Halal, Hormones-free, Kosher, Latex-free, Monosodium Glutamate (MSG)-free, Natural Latex Rubber-Free, Non-GMO, Not Listed In California Proposition 65, PAH-free, PFAS-Free, PFOS-free, PHO (Partially Hydrogenated Oil)-Free, PVC-free, Palm Oil-free, Paraben-free, Perfluorooctanoic Acid-free, Pesticide-free, Phthalates-free, Plasticizer-free, Preservative-free, Sugar-free, TSE-free, Tributyl Tin Compounds-Free, Triphenyl Tin Compounds-Free, Vegetarian

Certifications & Compliance: British Pharmacopeia (BP), Chinese Pharmacopeia (ChP), EXCiPACT, European Pharmacopeia (Ph. Eur.), European Regulation 396/2005/EC, FDA Compliant, FDA Food Safety Modernization Act (FSMA), Generally Recognized As Safe (GRAS), ICH Q3C, Japan Pharmacopeia (JP), Kosher, National Formulary (NF), Regulation (EU) No. 1272/2008, Regulation (EU) No. 231/2012, United States Pharmacopeia (USP), cGMP

Manufacturing Technology: Direct Compression, Dry Granulation, Wet Granulation

Synonyms: Crystalline cellulose, Micro Fibril Cellulose, Pyrocellulose

  • TypeDocument Name
View All Documents

Enhanced TDS

Identification & Functionality

Features & Benefits

Applications & Uses

Properties

Physical Form
Physico-Chemical Properties
ValueUnitsTest Method / Conditions
Loss on Drying (More restrictive than compendium)max. 6.0%-
Bulk Density0.25 - 0.37g/mL-
Identification (A,B,C,D)Pass--
Degree of Polymerizationmax. 350units-
pH (More restrictive than compendium)5.0 - 7.0--
Conductivitymax. 75μS/cm-
Residue on Ignition1.8 - 2.2%-
Water Soluble Substances (More restrictive than compendium)max. 0.24%-
Ether Soluble Substancesmax. 0.05%-
Heavy Metalsmax. 0.001%-
SolubilityPass--
Microbiological Values
ValueUnitsTest Method / Conditions
Total Aerobic Microbial Count (More restrictive than compendium)max. 100cfu/g-
Yeast and Mold Count (Total, More restrictive than compendium)max. 20cfu/g-
Pseudomonas aeruginosaAbsent/10g-
E. coliAbsent/10g-
Staphylococcus aureusAbsent/10g-
Salmonella SpeciesAbsent/10g-
Particle Size Distribution
ValueUnitsTest Method / Conditions
Particle Size (D10)15 - 30--
Particle Size (D50)45 - 80--
Particle Size (Air Jet, 60 mesh, 250 microns)max. 1.0wt%-
Particle Size (Air Jet, 200 mesh, 75 microns)10.0 - 30.0wt%-

Regulatory & Compliance

Technical Details & Test Data

Typical Nutrient Information/100g
  US EU/Australia/NZ
Estimated Caloric Value 0 Cal

190 Cal/ 794 kJoules

Calories from Fat 0 Cal 0 Cal
Total Fat 0 g 0 g
Saturated Fat 0 g 0 g
Trans-Fat 0 g 0 g
Polyunsaturated Fat 0 g 0 g
Monounsaturated Fat 0 g 0 g
Cholesterol 0 mg 0 mg
Sodium 5 mg 5 mg
Salt - g 0.01 g
Potassium 0 mg 0 mg
Total Carbohydrate 0 g 0 g
Sugars (Total) 0 g 0 g
Added Sugars 0 g 0 g
Starch 0 g 0 g
Total Dietary Fiber 95 g 95 g
Dietary Fiber (Soluble) 0 g 0 g
Dietary Fiber (Insoluble) 95 g 95 g
Protein 0 g 0 g
Vitamin A 0 mcg 0 mcg
Vitamin C 0 mg 0 mg
Vitamin D 0 mcg 0 mcg
Calcium 1 mg 1 mg
Iron 0 mg 0 mg
Magnesium 0 mg 0 mg
Moisture 3 g 3 g
Ash 2 g 2g
Organic acid 0 g 0 g

Storage & Handling

Shelf Life
4 years
Shelf Life Information

Store at ambient conditions. Keep containers sealed; material is very hygroscopic. Re-evaluation date is four (4) years from date of manufacture, if storage conditions stated above are observed. IFF recommends that after the above re-evaluation date, the customer perform the loss on drying test. Typical Degree Polymerization range for Avicel PH microcrystalline cellulose is 100 to 300.