Avicel® SMCC HD 90 comprising non-animal origin microcrystalline cellulose, is utilized in various pharmaceutical and nutraceutical applications. Employing direct compression, dry granulation, and wet granulation manufacturing technologies, it serves as a compression aid, filler, and immediate release agent.

Chemical Name: Cellulose, Microcrystalline

CAS Number: 9004-34-6

Labeling Claims: APE-free, Allergen-free, Aluminum-free, Antibiotics-free, BSE-free, Bisphenol A-free, Caffeine Free, Colorants-free, Dioxin-free, Dye Free, Glycerin-free, Halal, Hormones-free, Kosher, Latex-free, Monosodium Glutamate (MSG)-free, Natural Latex Rubber-Free, Non-GMO, PAH-free, PFAS-Free, PFOS-free, PHO (Partially Hydrogenated Oil)-Free, PVC-free, Palm Oil-free, Paraben-free, Perfluorooctanoic Acid-free, Pesticide-free, Phthalates-free, Plasticizer-free, Preservative-free, Sugar-free, TSE-free, Tributyl Tin Compounds-Free, Triphenyl Tin Compounds-Free, Vegetarian

Certifications & Compliance: British Pharmacopeia (BP), Chinese Pharmacopeia (ChP), EXCiPACT, European Pharmacopeia (Ph. Eur.), European Regulation 396/2005/EC, FDA Compliant, FDA Food Safety Modernization Act (FSMA), Generally Recognized As Safe (GRAS), ICH Q3C, Japan Pharmacopeia (JP), Kosher, National Formulary (NF), Regulation (EU) No. 1272/2008, Regulation (EU) No. 231/2012, United States Pharmacopeia (USP), cGMP

Manufacturing Technology: Direct Compression, Dry Granulation, Wet Granulation

Synonyms: Crystalline cellulose, Micro Fibril Cellulose, Pyrocellulose

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Enhanced TDS

Identification & Functionality

Features & Benefits

Applications & Uses

Properties

Physical Form
Physico-Chemical Properties
ValueUnitsTest Method / Conditions
Loss on Drying (More restrictive than compendium)max. 6.0%-
Bulk Density0.38 - 0.50g/mL-
Identification (A,B,C,D)Pass--
Degree of Polymerizationmax. 350units-
pH (More restrictive than compendium)5.0 - 7.0--
Conductivitymax. 75μS/cm-
Residue on Ignition1.8 - 2.2%-
Water Soluble Substances (More restrictive than compendium)max. 0.24%-
Ether Soluble Substancesmax. 0.05%-
Heavy Metalsmax. 0.001%-
SolubilityPass--
Microbiological Values
ValueUnitsTest Method / Conditions
Total Aerobic Microbial Count (More restrictive than compendium)max. 100cfu/g-
Yeast and Mold Count (Total, More restrictive than compendium)max. 20cfu/g-
Pseudomonas aeruginosaAbsent/10g-
E. coliAbsent/10g-
Staphylococcus aureusAbsent/10g-
Salmonella SpeciesAbsent/10g-
Particle Size Distribution
ValueUnitsTest Method / Conditions
Particle Size (D10)20 - 70--
Particle Size (D50)90 - 160--
Particle Size (Air Jet, 60 mesh, 250 microns)max. 8.0wt%-
Particle Size (Air Jet, 200 mesh, 75 microns)45.0 - 80.0wt%-
Note

This product meets the requirements for Residual Solvents (%) in the United States Pharmacopeia <467> and complies with the ICH Guide Q3C for Residual Solvents.

Regulatory & Compliance

Technical Details & Test Data

Typical Nutrient Information/100g
  US EU/Australia/NZ
Estimated Caloric Value 0 Cal

190 Cal/ 794 kJoules

Calories from Fat 0 Cal 0 Cal
Total Fat 0 g 0 g
Saturated Fat 0 g 0 g
Trans-Fat 0 g 0 g
Polyunsaturated Fat 0 g 0 g
Monounsaturated Fat 0 g 0 g
Cholesterol 0 mg 0 mg
Sodium 5 mg 5 mg
Salt -9 0.01 g
Potassium 0 mg 0 mg
Total Carbohydrate 0 g 0 g
Sugars (Total) 0 g 0 g
Added Sugars 0 g 0 g
Starch 0 g 0 g
Total Dietary Fiber 95 g 95 g
Dietary Fiber (Soluble) 0 g 0 g
Dietary Fiber (Insoluble) 95 g 95 g
Protein 0 g 0 g
Vitamin A 0 mcg 0 mcg
Vitamin C 0 mg 0 mg
Vitamin D 0 mcg 0 mcg
Calcium 1 mg 1 mg
Iron 0 mg 0 mg
Magnesium 0 mg 0 mg
Moisture 3 g 3 g
Ash 2 g 2 g
Organic acid 0 g 0 g

US: Calories = [(Total Carbs + Protein) * 4 Cal/g + (Fat * 9 Cal/g)]. Soluble fiber is included in Total Carbs. In the US, food manufacturers have the option to exclude the amount of insoluble fiber from the calorie calculation.
EU: Calories = ([Carbs (sugars + starch ) + Protein] * 4 Cal/g) + (Fat * 9 Cal/g) + (All dietary fiber * 2 Cal/g) + (Organic acids * 3 Cal/g)). In Europe, fiber is listed separately and is not included in the carb content. Other calorie conversion factors exist, none of which is relevant to this product.

Storage & Handling

Shelf Life
4 years