METHOCEL™ E5 Premium LV HPMC

1 of 50 products in this brand
METHOCEL™ E5 Premium LV HPMC is water-soluble and used in suspensions, granulation, and tablet coating. It functions as a binder, controlled release agent, film former, and gelling agent in pharmaceuticals and nutraceuticals, and as a binder in ceramics.

INCI Name: Methylcellulose

Chemical Name: Hydroxypropyl Methylcellulose

CAS Number: 9004-65-3

Dosage Form: Suspension, Tablets

Ingredient Origin: Plant Origin

Labeling Claims: Aluminum-free, Animal Products-free, Antibiotics-free, BSE-free, Bisphenol A-free, CMR Substances-free, Caffeine Free, Colorants-free, Dairy-free, Diethylene Glycol-free, Dioxin-free, Doping Substances-free, Endocrine Disruptor-free, Ethylene Glycol-free, Fragrance allergen-free, Hormones-free, Iodine-free, Irradiation-free, Kosher, Latex-free, Maleic Acid -Free, Monosodium Glutamate (MSG)-free, Non-GMO, PFAS-Free, PVC-free, Paraben-free, Pesticide-free, Phenylalanine-Free, Plasticizer-free, Potassium-free, Preservative-free, Quaternary Ammonium Salt-Free, Radionuclides Free, Residual Solvent -Free, Sewage Sludge Free, Steroids Free, TSE-free, Tributyltin (TBT) - Free

Synonyms: Hydroxypropyl methyl cellulose ether, Methyl hydroxypropyl cellulose, Cellulose hydroxypropyl methyl ether, 2-Hydroxypropyl methyl cellulose, 2-Hydroxypropyl methyl cellulose ether, Hydroxypropyl methyl cellulose, HPMC, Hypermellose, Hypromellose

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Enhanced TDS

Identification & Functionality

Chemical Family
Cellulose & Cellulosics,
Cellulose Ethers
Chemical Name
Hydroxypropyl Methylcellulose
INCI Name
Methylcellulose
Ingredient Origin
Plant Origin
Cosmetic Ingredients Functions
Thickener
Pharma & Nutraceuticals Functions
Binder,
Controlled Release Agent,
Film Former,
Gelling Agent,
Immediate Release Agent,
Mucoadhesive,
Solubilizer,
Sustained Release Agent,
Thickener,
Viscosity Modifier
Plastics & Elastomers Functions
Binder,
Emulsifier,
Film Former,
Lubricant (Internal),
Plasticizer,
Rheology Modifier,
Surfactant
Technologies
Cosmetic Ingredients,
Pharmaceuticals & Nutraceuticals
Product Families
Pharmaceuticals & Nutraceuticals — Excipients
Binders & Disintegrants,
Emulsifiers & Stabilizers,
Formulation & Processing Aids,
Modified & Controlled Release,
Pharmaceutical Coatings,
Solvents & Solubilizers
Cosmetic Ingredients — Functionals
Rheology Modifiers

Features & Benefits

Labeling Claims
Aluminum-free,
Animal Products-free,
Antibiotics-free,
BSE-free,
Bisphenol A-free,
CMR Substances-free,
Caffeine Free,
Colorants-free,
Dairy-free,
Diethylene Glycol-free,
Dioxin-free,
Doping Substances-free,
Endocrine Disruptor-free,
Ethylene Glycol-free,
Fragrance allergen-free,
Hormones-free,
Iodine-free,
Irradiation-free,
Kosher,
Latex-free,
Maleic Acid -Free,
Monosodium Glutamate (MSG)-free,
Non-GMO,
PFAS-Free,
PVC-free,
Paraben-free,
Pesticide-free,
Phenylalanine-Free,
Plasticizer-free,
Potassium-free,
Preservative-free,
Quaternary Ammonium Salt-Free,
Radionuclides Free,
Residual Solvent -Free,
Sewage Sludge Free,
Steroids Free,
TSE-free,
Tributyltin (TBT) - Free
Food Ingredients Features
Cold Water Dispersible
Materials Features
Anti-settling Properties,
Good Gelling Behaviour,
Good Thickening Properties,
Good pH Stability,
Improved Adhesion,
Non-Ionic,
Water Soluble,
Wide pH Range

Applications & Uses

Markets
Healthcare & Pharma,
Personal Care
Applications
Personal Care — Beauty & Care
Oral Care
Healthcare & Pharma — Drug Delivery & Care Solutions
Oral
Segments
Dietary Supplement,
Pharmaceutical
Applications
Pharmaceutical — Immediate release
Dietary Supplement — Immediate release
Application Format
Rinse Off
Dosage Form
Suspension,
Tablets
Manufacturing Technology
Granulation,
Tablet Coating
Oral Care Applications
Mouthwash,
Toothpaste

Properties

Physical Form
Powder
Soluble In
Cold Water Soluble,
Organic Solvent Soluble,
Propylene Glycol Soluble,
Water Soluble
Physical Properties
ValueUnitsTest Method / Conditions
pH (at 2% solution)*5.0 - 8.0-CE-8.7
Microbiological Values
ValueUnitsTest Method / Conditions
E. coli*Absent/gCE-92.1
Pseudomonas aeruginosa*Absent/1gCE-92.1
Salmonella*Absent/10gCE-92.1
Staphylococcus aureus*Absent/gCE-92.1
Yeast and Mold Count*max. 100/gCE-92.1
Total Plate Count*max. 100/gCE-92.1
Composition
ValueUnitsTest Method / Conditions
Hydroxypropoxyl Content*7.0 - 12.0%CE-91.25
Methanol Content (PPM, Residual Solvents)*28.0 - 30.0%CE-91.25
Sodium Chloride Content*max. 0.3%CE-15.2
Propylene Glycol*0.1%-
Dipropylene Glycol*0.1%-
Tripropylene Glycol*0.1%-
Dipropylene Glycol Monomethyl Ether*0.1%-
Specifications
ValueUnitsTest Method / Conditions
Opalescence*Pass-CE-91.4 According to EP
Color Evaluation*Pass-CE-91.4 According to EP
Transmittance*min. 79.0%CE-91.29
Identification*Pass-CE-91.5
Sulfated Ash Content (Residue on Ignition)*max. 1.5%CE-91.34
Moisture Content (Loss on Drying)*max. 5.0%CE-7.1
Apparent Viscosity*4.1 - 4.9mPa.sCE-91.9
Apparent Viscosity (Target)*4.5mPa.s-
Heavy Metals
ValueUnitsTest Method / Conditions
Heavy Metals (as Lead)*max. 20mg/KgCE-93.1
Screen Test
ValueUnitsTest Method / Conditions
Screen (< 63 micron, through 230 mesh)*min. 50%CE-91.30
Screen (< 149 micron, through 100 mesh)*min. 90%CE-91.30
Note

*NF and Ph. Eur. ID tests; “A” and “B” on a quarterly basis. ID tests “C” (NF and Ph. Eur.) and “D” (Ph.Eur.) will be completed by exception only.

Regulatory & Compliance

Certifications & Compliance
EXCiPACT,
European Pharmacopeia (Ph. Eur.),
FSSC 22000,
GMP,
ISO 14001,
ISO 9001,
Japan Pharmacopeia (JP),
National Formulary (NF),
Orthodox Union Kosher,
Regulation (EC) No. 1333/2008,
Regulation (EU) No. 67/548/EEC,
US DMF,
United States Pharmacopeia (USP)
Chemical Inventories
AICS (Australia),
AIIC (Australia),
CSCL (Japan),
DSL (Canada),
EINECS (EU),
ENCS (Japan),
IECSC (China),
ISHL (Japan),
KECI (Korea),
METI (Japan),
NDSL (Canada),
PICCS (Phillipines),
TSCA (USA)
Quality Standards
EN ISO 9001:2015,
GMP,
ICH Q3D

Packaging & Availability

Packaging Type
Bags,
Boxes,
Drums,
Super Sacks