- Functions:Disintegrant, Immediate Release Agent
- Manufacturing Technology:Direct Compression, Dry Granulation, Wet Granulation, Granulation, Extrusion
- Dosage Form:Effervescent Tablets, Tablets, Capsules, Granules, Orally Disintegrating Tablets (ODTs)
- Certifications & Compliance Search Terms:National Formulary (NF)
Ac-Di-Sol® Croscarmellose Sodium is an internally cross-linked sodium carboxymethylcellulose. It is the super disintegrant of choice for many immediate release formulations. Ac-Di-Sol® is an insoluble and hydrophilic polymer with excellent water uptake and rapid swelling properties; supporting faster disintegration and drug dissolution at lower use levels (2-3%).
Ac-Di-Sol® can be used in all manufacturing processes, including higher shear wet granulation, fluid bed granulation, direct compression, and dry granulation. Besides its disintegrating properties, Ac-Di-Sol® Croscarmellose Sodium has good binding and compaction properties.