Ac-Di-Sol® SD - 711

1 of 2 products in this brand
Ac-Di-Sol® Croscarmellose Sodium is an internally cross-linked sodium carboxymethylcellulose. It is the super disintegrant of choice for many immediate release formulations. Ac-Di-Sol® is an insoluble and hydrophilic polymer with excellent water uptake and rapid swelling properties; supporting faster disintegration and drug dissolution at lower use levels (2-3%). Ac-Di-Sol® can be used in all manufacturing processes, including higher shear wet granulation, fluid bed granulation, direct compression, and dry granulation. Besides its disintegrating properties, Ac-Di-Sol® Croscarmellose Sodium has good binding and compaction properties.

Chemical Name: Croscarmellose Sodium

CAS Number: 74811-65-7

Dosage Form: Capsules, Effervescent Tablets, Granules, Orally Disintegrating Tablets (ODTs), Tablets

Manufacturing Technology: Direct Compression, Dry Granulation, Extrusion, Granulation, Wet Granulation

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Enhanced TDS

Identification & Functionality

Applications & Uses

Properties

Physical Form
Physico-Chemical Properties
ValueUnitsTest Method / Conditions
IdentificationPass--
Sodium Chloride and N-Arachidonylglycine*max. 0.50%-
Degree of Substitution*0.63 - 0.85--
Content of Water Soluble Material*1.0 - 5.5%-
Setting Volume10.0 - 30.0mL-
pH*5.9 - 7.0--
Loss on Drying*max. 6.0%-
Sulfated Ash Content14.0 - 28.0%-
Microbiological Values
ValueUnitsTest Method / Conditions
Total Aerobic Countmax. 100*cfu/g-
Total Fungi (Yeast and Mold)*max. 20cfu/g-
E. coliAbsent--
Pseudomonas aeruginosaAbsent--
Staphylococcus aureusAbsent--
Salmonella SpeciesAbsent--
Specifications
ValueUnitsTest Method / Conditions
Residual Solventmax. 0.01%-
Particle Size Distribution (D10)max. 25μmMalvern Ld.
Particle Size Distribution (D50)25-55μmMalvern Ld.
Particle Size Distribution (D90)min. 60μmMalvern Ld.
Heavy Metals
ValueUnitsTest Method / Conditions
Heavy Metalsmax. 0.001%-
Note

*More restrictive than compendium .

Nutritional Information

Typical Nutrient Information/100g

US EU/Australia/NZ
Estimated Caloric Value 146 Cal

146 Cal/ 610 kJoules

Calories from Fat 0 Cal 0 Cal
Total Fat 0 g 0 g
Saturated Fat 0 g 0 g
Trans-Fat 0 g 0 g
Polyunsaturated Fat 0 g 0 g
Monounsaturated Fat 0 g 0 g
Cholesterol 0 mg 0 g
Sodium 7000 mg 7000 mg
Salt 0 g 17.50 g
Potassium 4 mg 4 mg
Total Carbohydrate 73 g 0 g
Sugars (Total) 0 g 0 g
Added Sugars 0 g 0 g
Starch 0 g 0 g
Total Dietary Fiber 0 g 73 g
Dietary Fiber (Soluble) 0 g 73 g
Dietary Fiber (Insoluble) 0 g 0 g
Protein 0 g 0 g
Vitamin A 0 mcg 0 mcg
Vitamin C 0 mg 0 mg
Vitamin D 0 mcg 0 mcg
Calcium 5 mg 5 mg
Iron 0 mg 0 mg
Magnesium 0 mg 0 mg
Moisture 8 g 8 g
Ash 19 g 19 g
Organic acid 0 g 0 g

Regulatory & Compliance

Certifications & Compliance Search Terms
Chemical Inventories
Quality Standards

Storage & Handling

Shelf Life
3 years
Storage Conditions

Store at ambient conditions. Keep containers sealed; material is very hygroscopic.Re-evaluation requirements: IFF recommends that after the above re-evaluation date, the customer perform the loss on drying test.